The animation was really nice, the voice acting and audio quality were solid.
It's just a pity that you used a meme as the punchline. I feel like, with your talent, you are capable of creating a video that is funny based on its own merits. It's very tacky and lazy to rely on memes to bring humour to your videos because you're not actually coming up with anything unique or original, you're just riding on someone else's joke.
I feel like you could have done this video without the use of the meme, you could have just had the last remaining bacteria crying or freaking out or something.
If you keep up the good work and practice writing more original material, you will go far.
newgrounds.com — Your #1 online entertainment & artist community! All your base are belong to us.